How much less ecological validity, then, would research in animal models of different neuropsychiatric states have for patients in clinical practice? This explains why drugs that work in animal models often fail in humans. In fact, these cognitive and psychomotor tests, especially when based on computerized tasks, have no parallel in everyday life. Thus, laboratory studies of the neuropsychological and psychomotor impairments produced by psychotropic drugs have poor ecological validity because what is studied in relaxed, rested, and healthy subjects tested in a controlled environment is very different from demands that stressed patients face in everyday life. Ecological validity was originally invoked in the context of laboratory studies that required to be generalized to real-life situations.
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